Senior Scientist specializing in antibody engineering and conjugation. Specific expertise in maleimide conjugations and antibody-oligo conjugates,
I am looking for someone who has experience with antibody-oligo conjugates -specifically site-specific conjugation chemistries to conjugate oligonucleotides to antibodies. This is a new role at a global pharma in the Boston area.
- experience using maleimide conjugation with antibodies.
- experience optimizing the reactions (pH, buffer, concentration screening).
- preparing conjugates at various scales from mgs all the way to grams
- characterization experience with the conjugates: HPLC, SEC, HIC, IEX, LC/MS
- understanding of antibody structure and chemical modification strategies using various formats (IgG, Fab, scFv)
